BSJ-04-132
Names
[ CAS No. ]:
2349356-39-2
[ Name ]:
BSJ-04-132
Biological Activity
[Description]:
BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1].
[Related Catalog]:
[Target]
CDK4/D1:50.6 nM (IC50)
CDK6/D1:30 nM (IC50)
[In Vitro]
BSJ-04-132 (0.1-5 μM; for 4 hours) only resultes in degradation of CDK4 in WT cells, not CDK6 and IKZF1/3[1]. Western Blot Analysis[1] Cell Line: Wildtype (WT) or Crbn-/- Jurkat cells Concentration: 0.1, 0.5, 1, 5 μM Incubation Time: For 4 hours Result: Only resulted in degradation of CDK4 in WT cells, not CDK6 and IKZF1/3.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C42H49N11O7
[ Molecular Weight ]:
819.91
Safety Information
[ Hazard Codes ]:
Xi