DDO-5936
Names
[ CAS No. ]:
2355377-13-6
[ Name ]:
DDO-5936
[Synonym ]:
Glycine, N-[4-[[2-(1-pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]-
Biological Activity
[Description]:
DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer[1].
[Related Catalog]:
[Target]
Hsp90-Cdc37 PPI[1]
[In Vitro]
DDO-5936 is a Hsp90-Cdc37 PPI inhibitor with potency and specificity through binding to a critical site on Hsp90 involving Glu47[1].
[In Vivo]
DDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group[1]. DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency[1]. Animal Model: Mice[1] Dosage: 0~80 mg/kg Administration: P.o. Result: Showed a moderate effect at the high dose group.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C25H29N5O4S
[ Molecular Weight ]:
495.59
[ Storage condition ]:
-20°C