DENV-IN-5

Names

[ Name ]:
DENV-IN-5

Biological Activity

[Description]:

DENV-IN-5 (Compound 4b) is a dengue virus (DENV) inhibitor with EC50s of 1.47, 9.23, 7.08 and 8.91 μM against DENV-I ∼ IV replication, respectively. DENV-IN-5 also inhibits HIV-1IIIB strain with an EC50 of 0.1512 μM[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[Target]

HIV (IIIB):0.1512 μM (EC50)

DENV-I:1.47 μM (EC50)

DENV-II:9.23 μM (EC50)

DENV-III:7.08 μM (EC50)

DENV-IV:8.91 μM (EC50)

[References]

[1]. Rui RM, et al. C6-structural optimizations of 2-aryl-1H-pyrazole-S-DABOs: From anti-HIV to anti-DENV activity. Bioorg Chem. 2022 Feb;119:105494.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₅ClF₂N₄OS

[ Molecular Weight ]:
478.99

DENV-IN-5

Names

Biological Activity

Chemical & Physical Properties

Related Compounds