ZN-c3

Names

[ Name ]:
ZN-c3

Biological Activity

[Description]:

ZN-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). ZN-c3 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Wee1

[Target]

IC50: 3.9 nM (Wee1)[1]

[In Vitro]

ZN-c3 IC50 is 103 nM in H23c cells[1].

[In Vivo]

ZN-c3 (80 mg/kg; p.o.; 28 days) can effectively shrank tumors at 80 mg/kg as a single agent[1]. ZN-c3 shows excellent exposures and bioavailability in the dog PK study[1].

[References]

[1]. Huang PQ, et al. Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer [published online ahead of print, 2021 Aug 23]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01121.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₄N₈O₂

[ Molecular Weight ]:
526.63

[ Storage condition ]:
-20°C

ZN-c3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds