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CDK4/6-IN-6

Names

[ CAS No. ]:
2380321-51-5

[ Name ]:
CDK4/6-IN-6

Biological Activity

[Description]:

CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

Cdk4/cyclin D1:0.6 nM (Ki)

cdk6/cyclin D3:13.9 nM (Ki)


[In Vitro]

CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1].

[References]

[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H27ClFN5O3

[ Molecular Weight ]:
463.93

Related Compounds