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NF-κB/MAPK-IN-1

Names

[ CAS No. ]:
2413940-56-2

[ Name ]:
NF-κB/MAPK-IN-1

Biological Activity

[Description]:

NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

NF-κB

p38

COX-2


[References]

[1]. Hu YS, et al. Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo. Bioorg Chem. 2020 May;98:103735.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H27NO7

[ Molecular Weight ]:
477.51

Related Compounds