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USP7-IN-7

Names

[ CAS No. ]:
2413944-70-2

[ Name ]:
USP7-IN-7

Biological Activity

[Description]:

USP7-IN-7 (compound 124) is a USP7 inhibitor with an IC50 value ＜10 nM. USP7-IN-7 shows cytotoxicity against p53-mutant cancer cell lines, p53 wild-type blood cancer and neuroblastoma cell lines with low nanomolar values. USP7-IN-7 can be used for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase

[In Vitro]

USP7-IN-7 (0-1 μM) 对 p53 野生型血液癌细胞系具有细胞毒性，对 M07e，OCI-AML5，MOLM13 和 MM.IS 的 CC50 值分别为 0.2，0.2，0.4 和 0.1 μM[1]。 USP7-IN-7 (0-2 μM) 对 p53 野生型神经母细胞瘤细胞株具有细胞毒性，对 SH-SY5Y，CHP-134 和 NB-1 的 CC50 值分别为 1.9，0.6 和 0.5 μM[1]。 USP7-IN-7 (0-25 μM) 对 p53 突变癌细胞系具有细胞毒性，对 H526，LA-N-2 和 SK-N-DZ 的 CC50 值分别为 0.5，0.2 和 0.2 μM[1]。

[References]

[1]. Biannic, Berenger, et al. UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF. US20200095260. 2019.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H28ClN3O3S

[ Molecular Weight ]:
510.05

Related Compounds