Anticancer agent 75

Anticancer agent 75 is a potent anticancer agent. Anticancer agent 75 shows cytotoxicity and selectivity in cancer cell lines. Anticancer agent 75 shows cytotoxicity to normal human kidney cell lines is at least 35 times lower than that of the Doxorubicin standard. Anticancer agent 75 shows good activity of antiplasmodial[1].

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

Research Areas >> Infection

Topoisomerase II

Anticancer agent 75 (Compounds 3h) shows good anticancer activity and at least 35 times less toxic than Doxorubicin[1]. Anticancer agent 75 (Compounds 3h) inhibits cancer cell growth with IC50 values of 333.83 µM, 13.39 µM, 15.31 µM, 15.58 µM, and 4.90 µM for HEK-293, HuCCA-1, A549, HepG2, and MOLT-3, respectively[1].

[1]. Bhornrawin Akkachairin, et al. Synthesis of Neocryptolepines and Carbocycle-Fused Quinolines and Evaluation of Their Anticancer and Antiplasmodial Activities. Journal Pre-proofs. 2020, 98: 103732.