PARP7-IN-16

Names

[ CAS No. ]:
2435657-10-4

[ Name ]:
PARP7-IN-16

Biological Activity

[Description]:

PARP7-IN-16 (compound 36) is a potent, selective and orally active inhibitor of PARP-1/2/7, with IC50s of 0.94, 0.87 and 0.21 nM, respectively. PARP7-IN-16 can be used for the research of breast cancer and prostate cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> PARP
Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

PARP-1:0.94 nM (IC50)

PARP-2:0.87 nM (IC50)

PARP-7:0.21 nM (IC50)


[References]

[1]. Zhou J, et, al. Discovery of Quinazoline-2,4(1 H,3 H)-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J Med Chem. 2023 Oct 26;66(20):14095-14115.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H26FN4NaO4

[ Molecular Weight ]:
488.49

Related Compounds