Antifungal agent 33

Names

[ CAS No. ]:
2445277-57-4

[ Name ]:
Antifungal agent 33

Biological Activity

[Description]:

Antifungal agent 33 (compound 4e) is a potent antifungal agent. Antifungal agent 33 exhibits remarkable antifungal activity against C. albicans, with a MIC of 16 μg/mL. Antifungal agent 33 shows potent inhibitory activity against Lanosterol 14α-demethylase (CYP51), with an IC50 of 0.19 μg/mL[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Morcoss MM, et al. Design, synthesis, mechanistic studies and in silico ADME predictions of benzimidazole derivatives as novel antifungal agents. Bioorg Chem. 2020 Aug;101:103956.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H14ClN5O3

[ Molecular Weight ]:
419.82

Related Compounds