PARP1-IN-11

Names

[ Name ]:
PARP1-IN-11

Biological Activity

[Description]:

PARP1-IN-11 (compound 49) is a potent PARP1 inhibitor with IC50 value of 0.082 µM. PARP1-IN-11 shows complete inhibition of PARP2 and substantially inhibits PARP3, TNKS1 and TNKS2[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

PARP1:0.082 μM (IC50)

PARP2

TNKS1

TNKS2

[References]

[1]. Shao X, et al. Synthesis of 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide and 3-oxo-3,4-dihydrobenzo[b][1,4]oxazine-8-carboxamide derivatives as PARP1 inhibitors. Bioorg Chem. 2020 Sep;102:104075.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₂N₂O₄

[ Molecular Weight ]:
296.28

PARP1-IN-11

Names

Biological Activity

Chemical & Physical Properties

Related Compounds