2'-Deoxyguanosine 5'-(Tetrahydrogen Triphosphate)

Names

[ Name ]:
2'-Deoxyguanosine 5'-(Tetrahydrogen Triphosphate)

[Synonym ]:
deoxyguanosinetriphosphate
2'-deoxy-GTP
5'-deoxyguanosine triphosphate
DGTP LI-SALT
deoxy-gtp
5'-DGTP
2'-DEOXYGUANOSINE-5'-TRIPHOSPHORIC ACID, DISODIUM
DGTP,LI
DGTP,NA2H2
2'-Deoxyguanosine 5'-(Tetrahydrogen Triphosphate)
EINECS 219-887-2

Biological Activity

[Description]:

dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6.

Chemical & Physical Properties

[ Density]:
2.63g/cm3

[ Boiling Point ]:
989.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₆N₅O₁₃P₃

[ Molecular Weight ]:
507.18

[ Flash Point ]:
552.2ºC

[ PSA ]:
313.96000

[ LogP ]:
0.15110

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.904

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8782500

CHEMICAL NAME :: Guanosine, 2'-deoxy-, 5'-(tetrahydrogen triphosphate)

CAS REGISTRY NUMBER :: 2564-35-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H16-N5-O13-P3

MOLECULAR WEIGHT :: 507.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 356,261,1996