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CDK5-IN-3

Names

[ CAS No. ]:
2639542-32-6

[ Name ]:
CDK5-IN-3

Biological Activity

[Description]:

CDK5-IN-3 (compound 11) is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD)[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Research Areas >> Metabolic Disease

[Target]

Cdk5/p25:0.6 nM (IC50)

CDK2/CycA:18 nM (IC50)


[References]

[1]. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022 Feb 24;65(4):3575-3596.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H26N4O

[ Molecular Weight ]:
362.47

Related Compounds