RMS-07

Names

[ Name ]:
RMS-07

Biological Activity

[Description]:

RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC50 of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region[1].

[Related Catalog]:

Signaling Pathways >> Cytoskeleton >> Mps1

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> Mps1

[Target]

IC50：13.1 nM （Monopolar Spindle Kinase 1 (MPS1/TTK)）.

[References]

[1]. Ricardo A M Serafim, et al. Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. J Med Chem. 2022 Feb 24;65(4):3173-3192.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₅H₄₀N₈O₂

[ Molecular Weight ]:
604.74

RMS-07

Names

Biological Activity

Chemical & Physical Properties

Related Compounds