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SKLB-197

Names

[ CAS No. ]:
2713577-16-1

[ Name ]:
SKLB-197

Biological Activity

[Description]:

SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR
Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR

[Target]

ATR:0.013 μM (IC50)


[References]

[1]. Bin H,et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187

Chemical & Physical Properties

[ Molecular Formula ]:
C25H24N6O

[ Molecular Weight ]:
424.50

Related Compounds