Werner syndrome RecQ helicase-IN-2

Names

[ Name ]:
Werner syndrome RecQ helicase-IN-2

Biological Activity

[Description]:

Werner syndrome RecQ helicase-IN-2 (example 57) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[In Vitro]

Werner syndrome RecQ helicase-IN-2 (example 57)作用于 WRN ATPase 的IC50 值为100 nM，作用于 SW48和 DLD1 WRN-KO 细胞系的GI50 值分别是100 nM和大于10 μM[1]。

[References]

[1]. Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₄F₃N₉O₅

[ Molecular Weight ]:
681.66

Werner syndrome RecQ helicase-IN-2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds