HDAC-IN-63

Names

[ CAS No. ]:
2920046-95-1

[ Name ]:
HDAC-IN-63

Biological Activity

[Description]:

HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC50: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively). HDAC-IN-63 inhibits MV4-11 cell proliferation (IC50: 92 nM. HDAC-IN-63 induces apoptosis and arrests cell cycle in MV4-11 cells. HDAC-IN-63 can be used for research of acute myeloid leukemia (AML)[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC

[Target]

0.844 and 30.0 nM for FLT3 and HDAC1[1]


[References]

[1]. Wang Z, et al. Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy. Eur J Med Chem. 2023 Aug 28;260:115759.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H26Cl2N6O3

[ Molecular Weight ]:
529.42

Related Compounds