4-(2,4-Dichlorophenyl)-1,4-dihydro-[1,3,5]triazino[1,2-a]benzimidazol-2-amine

Names

[ Name ]:
4-(2,4-Dichlorophenyl)-1,4-dihydro-[1,3,5]triazino[1,2-a]benzimidazol-2-amine

[Synonym ]:
1,3,5-triazino[1,2-a]benzimidazol-2-amine, 4-(2,4-dichlorophenyl)-3,4-dihydro-
1,3,5-Triazino[1,2-a]benzimidazol-2-amine, 4-(2,4-dichlorophenyl)-4,10-dihydro-
4-(2,4-Dichlorophenyl)-4,10-dihydro[1,3,5]triazino[1,2-a]benzimidazol-2-amine
MFCD06592467

Biological Activity

[Description]:

Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisomerase II inhibitor 14 induces apoptosis, and arrests cell cycle at S phase. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[In Vivo]

Topoisomerase II inhibitor 14 (compound 2f)

[References]

[1]. Al-Karmalawy AA, et al. Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments. Eur J Med Chem. 2023 Nov 5;259:115661.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
493.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₁Cl₂N₅

[ Molecular Weight ]:
332.19

[ Flash Point ]:
252.3±31.5 °C

[ Exact Mass ]:
331.039154

[ LogP ]:
3.08

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.801