Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI)

Names

[ Name ]:
Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI)

Biological Activity

[Description]:

BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[References]

[1]. RPA194, rRNA synthesis, 45S Rrna, anticancerKarita Peltonen, et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014 Nov;13(11):2537-46.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₇N₃

[ Molecular Weight ]:
251.32600

[ Exact Mass ]:
251.14200

[ PSA ]:
51.80000

[ LogP ]:
4.18000

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%