[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide

Names

[ Name ]:
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide

[Synonym ]:
(Gly1,Ser3·22,Gln4·34,Thr6,Arg19,Tyr21,Ala23·31,Aib32)-Pancreatic Polypeptide (human)

Biological Activity

[Description]:

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[Target]

hY5 receptor:0.24 nM (IC50)

hY1 receptor:530 nM (IC50)

hY2 receptor:>500 nM (IC50)

hY4 receptor:51 nM (IC50)

[In Vitro]

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide has IC50s of 530 nM, >500 nM, 51 nM for binding to the hY1, hY4, hY2 receptors[1].

[In Vivo]

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide (0.2, 2 nmol/rat) induces a high amount of food intake in a dose-dependent manner in adult male rats weighing 340-400 g[1].

[References]

[1]. C Cabrele , et al. The first selective agonist for the neuropeptide YY₅ receptor increases food intake in rats. J Biol Chem. 2000 Nov 17;275(46):36043-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈₃H₂₈₀N₅₇O₅₄S₂