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Indirubin-3'-monoxime-5-sulphonic acid

Names

[ CAS No. ]:
331467-05-1

[ Name ]:
Indirubin-3'-monoxime-5-sulphonic acid

[Synonym ]:
3-[3-(Hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid
indirubin-3'-monoxime-5-sulphonic acid
A05-A11B1-II

Biological Activity

[Description]:

Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

CDK1:5 nM (IC50)

CDK5:7 nM (IC50)

GSK-3β:80 nM (IC50)


[References]

[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H11N3O5S

[ Molecular Weight ]:
357.34

[ Exact Mass ]:
357.04200

[ PSA ]:
140.23000

[ LogP ]:
1.16390

Related Compounds