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Aurora Kinase Inhibitor II

Names

[ CAS No. ]:
331770-21-9

[ Name ]:
Aurora Kinase Inhibitor II

[Synonym ]:
quinazoline deriv. 1
Aurora Kinase Inhibitor II
4-(4'-Benzamidoanilino)-6,7-dimethoxyquinazoline
Anilinoquinazoline1

Biological Activity

[Description]:

Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Aurora Kinase
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase

[Target]

Aurora A:310 nM (IC50)

Aurora B:240 nM (IC50)


[In Vitro]

Aurora kinase inhibitor-2 (Compound 1) shows excellent levels of Aurora A enzyme inhibition and is also effective in an MCF7 cellular anti-proliferative assay (IC50 value of 1.25 µM)[2].

[References]

[1]. Andrew A Mortlock, et al. Progress in the development of selective inhibitors of aurora kinases. Curr Top Med Chem. 2005;5(8):807-21.

[2]. Nicola M Heron, et al. SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1320-3.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H20N4O3

[ Molecular Weight ]:
400.43000

[ Exact Mass ]:
400.15400

[ PSA ]:
85.37000

[ LogP ]:
4.78890

Related Compounds