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Tesetaxel

Names

[ CAS No. ]:
333754-36-2

[ Name ]:
Tesetaxel

[Synonym ]:
(2R,4S,6S,7R,10R,13S,14R,15S,16S,18S)-13-Acetoxy-4-[(dimethylamino)methyl]-18-{[(2R,3S)-3-(3-fluoro-2-pyridinyl)-2-hydroxy-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoyl]oxy}-16-hydroxy-7,19,2 ;0,20-tetramethyl-3,5,11-trioxapentacyclo[14.3.1.0.0.0]icos-1(19)-en-15-yl benzoate
2-Pyridinepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-3-fluoro-α-hydroxy-, (2aS,2bR,3S,4S,6S,8aR,10S,11aS,11bR,13aR)-2a-(acetyloxy)-3-(benzoyloxy)-10-[(dimethylamino)methyl]-2a,2b,3 ,4,5,6,8a,11a,11b,12,13,13a-dodecahydro-4-hydroxy-7,11b,14,14-tetramethyl-4,8-methano-2H-[1,3]dioxolo[3,4]cyclodeca[1,2-d]-1-benzoxet-6-yl ester, (αR,βS)-
Tesetaxel

Biological Activity

[Description]:

Tesetaxel is a orally active, semisynthetic microtubule inhibitor of the taxane class for the treatment of cancer, including colorectal and gastric cancer.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[References]

[1]. Shionoya M, Jimbo T, Kitagawa M, Soga T, Tohgo A. DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo. Cancer Sci. 2003;94(5):459-466.

[2]. Saif MW, Sarantopoulos J, Patnaik A, Tolcher AW, Takimoto C, Beeram M. Tesetaxel, a new oral taxane, in combination with capecitabine: a phase I, dose-escalation study in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2011;68(6):1565-1573.

Chemical & Physical Properties

[ Molecular Formula ]:
C46H60FN3O13

[ Molecular Weight ]:
881.99

Related Compounds