2’-O-Methyl-4-thiouridine

Names

[ Name ]:
2’-O-Methyl-4-thiouridine

[Synonym ]:
1-(2-O-Methyl-β-D-ribofuranosyl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone
2(1H)-Pyrimidinone, 3,4-dihydro-1-(2-O-methyl-β-D-ribofuranosyl)-4-thioxo-

Biological Activity

[Description]:

2’-O-Methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₁₀H₁₄N₂O₅S

[ Molecular Weight ]:
274.29

[ Exact Mass ]:
274.062347

[ LogP ]:
0.00

[ Index of Refraction ]:
1.664