Tirandamycin A

Names

[ Name ]:
Tirandamycin A

[Synonym ]:
TIRANDAMYCIN
tirandamycin-A

Biological Activity

[Description]:

Tirandamycin A, an antibiotic, is a bacterial RNA polymerase inhibitor. Tirandamycin A has antiamoebic and antibacterial properties[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

A 60 μM treatment with Tirandamycin A results in a slightly stronger inhibition, demonstrating a 84.2% reduction in growth of Entamoeba histolytica HM-1:IMSS and 64.8% reduction in growth by Entamoeba histolytica Col. Tirandamycin A inhibits chain initiation and elongation of bacterial RNA polymerase without acting on mammalian polymerases[1].

[References]

[1]. Avelina Espinosa, et al. Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A. Parasitol Res. 2012 Dec;111(6):2473-7.

[2]. H Hagenmaier, et al. Metabiolic products of microorganisms. Tirandamycin B(author's transl). Arch Microbiol. 1976 Aug;109(1-2):65-74.

Chemical & Physical Properties

[ Density]:
1.314g/cm3

[ Boiling Point ]:
560.1ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₇NO₇

[ Molecular Weight ]:
417.45200

[ Flash Point ]:
292.5ºC

[ Exact Mass ]:
417.17900

[ PSA ]:
114.46000

[ LogP ]:
1.84130

[ Index of Refraction ]:
1.577

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY7625500

CHEMICAL NAME :: 3-Pyrrolin-2-one, 4-hydroxy-3-(4-methyl-6-(1,2,7-trimethyl-5-oxo-3,9,10 - trioxatricyclo(4.3.1.0(sup 2,4))dec-8-yl)-2,4-heptadienoyl)-, (E,E)-

CAS REGISTRY NUMBER :: 34429-70-4

LAST UPDATED :: 198309

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H27-N-O7

MOLECULAR WEIGHT :: 417.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,69,1981