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8-NH2-ATP

Names

[ CAS No. ]:
35874-49-8

[ Name ]:
8-NH2-ATP

[Synonym ]:
8-Amino-ATP
Amino-8-ATP
8-AMINOADENOSINE-5'-O-TRIPHOSPHATE

Biological Activity

[Description]:

8-NH2-ATP, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado is reported to be potent as shown by induction of apoptosis-related cleavage of poly (ADP-ribose) polymerase[1][2].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Research Areas >> Metabolic Disease

[In Vitro]

The extensive cellular accumulation of 8-NH2-ATP has an inhibitory effect on both RNA and DNA synthesis in both glucocorticoid-sensitive and glucocorticoid-resistant myeloma cell lines[1][2].

[References]

[1]. Nancy L Krett, et al. 8-amino-adenosine is a potential therapeutic agent for multiple myeloma. Mol Cancer Ther. 2004 Nov;3(11):1411-20.

[2]. Yuji Matsuzaki, et al. ATP-association to intrabacterial nanotransportation system in Vibrio cholera. Med Mol Morphol. 2015 Dec;48(4):225-34.

Chemical & Physical Properties

[ Molecular Formula ]:
C10H17N6O13P3

[ Molecular Weight ]:
522.19600

[ Exact Mass ]:
522.00700

[ PSA ]:
334.58000

Related Compounds