1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione

Names

[ Name ]:
1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione

[Synonym ]:
5'-Amino-2',5'-dideoxyuridin
5'-Amino-2'-deoxyuridine
5'-NH2-2'-dU
Uridine,5'-amino-2',5'-dideoxy
5'-amino-2',5'-dideoxyuridine

Biological Activity

[Description]:

5′-Amino-2′,5′-dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.466g/cm3

[ Molecular Formula ]:
C₉H₁₃N₃O₄

[ Molecular Weight ]:
227.22

[ Exact Mass ]:
227.09100

[ PSA ]:
110.34000

[ Index of Refraction ]:
1.601

1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-oxolan-2-yl]pyrimidine-2,4-dione

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds