2,4-Thiazolidinedione,5-[(2-nitrophenyl)methylene]-

Names

[ Name ]:
2,4-Thiazolidinedione,5-[(2-nitrophenyl)methylene]-

[Synonym ]:
5-(2-nitro-benzylidene)-thiazolidine-2,4-dione
5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione
5-(2-Nitro-benzyliden)-thiazolidin-2,4-dion

Biological Activity

[Description]:

5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione (Compound 4) has antimicrobial, anti-diabetic and antioxidant activities. 5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione inhibits B. subtilis, S. aureus, K. pneumonia, E. coli, and S. typhi with MICs of 4.5-9.9 μΜ/mL, and inhibits A. niger and C. albicans with MICs of 4.99 μΜ/mL[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Elkamhawy A, et al. Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents. Eur J Med Chem. 2020 Feb 15;188:111955.

Chemical & Physical Properties

[ Density]:
1.595g/cm3

[ Molecular Formula ]:
C₁₀H₆N₂O₄S

[ Molecular Weight ]:
250.23

[ Exact Mass ]:
250.00500

[ PSA ]:
117.29000

[ LogP ]:
2.77070

[ Index of Refraction ]:
1.732

[ Storage condition ]:
-20℃

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%