N6-Cyclohexyladenosine

Names

[ Name ]:
N6-Cyclohexyladenosine

[Synonym ]:
N6-Cyclohexyladenosine

Biological Activity

[Description]:

N6-Cyclohexyladenosine is a selective A1 receptor agonist (EC50 = 8.2 nM). IC50 value: 8.2 nM (EC50)Target: A1 receptorin vivo: N6-Cyclohexyladenosine exerts anticonvulsant effects and protects against neuronal death. CHA was also found to inhibit the pressor effects of lumbar sympathetic nerve stimulation in rats.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Asghari AA, et al. Adenosine A1 receptor agonist, N6-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; electrophysiological and histopathological studies. J Neurol Sci. 2013 Feb 15;3

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.71g/cm3

[ Boiling Point ]:
675.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₂₃N₅O₄

[ Molecular Weight ]:
349.38500

[ Flash Point ]:
362.1ºC

[ Exact Mass ]:
349.17500

[ PSA ]:
125.55000

[ LogP ]:
0.25540

[ Index of Refraction ]:
1.787

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Articles

An adenosine kinase inhibitor, ABT-702, inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat.

Neuropharmacology 97 , 160-70, (2015)

Adenosine kinase (AK) inhibitor is a potential candidate for controlling pain, but some AK inhibitors have problems of adverse effects such as motor impairment. ABT-702, a non-nucleoside AK inhibitor,...

IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection.

Biochem. Biophys. Res. Commun. 449(4) , 477-82, (2014)

Several diseases are related to retinal ganglion cell death, such as glaucoma, diabetes and other retinopathies. Many studies have attempted to identify factors that could increase neuroprotection aft...

The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice.

Neuropharmacology 72 , 1-8, (2013)

Adenosine agonists or low doses of morphine exert anti-convulsant effects in different models of seizures. On the other hand, a tight interaction has been reported between morphine and adenosine in va...