MethADP

Names

[ Name ]:
MethADP

[Synonym ]:
Dimethylepoxypropionamide
3,3-Dimethyl-glycidsaeure-amid
Adenosine 5'-methylenediphosphate
9-{5-O-[Hydroxy(phosphonomethyl)phosphoryl]pentofuranosyl}-9H-pur in-6-amine
2-Aminocarbonyl-3-methyloxiran
3,3-dimethyl-oxiranecarboxylic acid amide
2,3-Epoxy-3-methylbutyramide
Oxiranecarboxamide,3,3-dimethyl
BUTYRAMIDE,2,3-EPOXY-3-METHYL
Dimethylepoxypropionamide [French]

Biological Activity

[Description]:

MethADP is a specific CD73 inhibitor.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

Research Areas >> Cancer

[Target]

CD73[1].

[In Vitro]

MethADP (AMP-CP: 20 μM) causes a marked inhibition of adenosine formation (0.96±0.96 μM) compared to untreated controls (9.6±1.5 μM) in A498 and RT4 cells, and MethADP (100 μM) completely inhibits the adenosine formation[1].

[References]

[1]. Mohlin C, et al. Studies of the extracellular ATP-adenosine pathway in human urinary tract epithelial cells. Pharmacology. 2009;84(4):196-202.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
2.35g/cm3

[ Boiling Point ]:
895.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₇N₅O₉P₂

[ Molecular Weight ]:
425.22800

[ Flash Point ]:
495.4ºC

[ Exact Mass ]:
425.05000

[ PSA ]:
242.99000

[ Index of Refraction ]:
1.885

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

DownStream

Articles

Identification of critical ligand binding determinants in Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase.

J. Med. Chem. 52 , 5485-95, (2009)

Mycobacterium tuberculosis adenosine-5'-phosphosulfate (APS) reductase is an iron-sulfur protein and a validated target to develop new antitubercular agents, particularly for the treatment of latent i...

Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus.

Immunity 38(3) , 555-69, (2013)

Monocyte-derived macrophages are essential for recovery after spinal cord injury, but their homing mechanism is poorly understood. Here, we show that although of common origin, the homing of proinflam...

Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling

Structure 20(12) , 2161-73, (2012)

In vertebrates ecto-5′-nucleotidase (e5NT) catalyzes the hydrolysis of extracellular AMP to adenosine and represents the major control point for extracellular adenosine levels. Due to its pivotal role...