2-(6-amino-8-hydrazinyl-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Names

[ Name ]:
2-(6-amino-8-hydrazinyl-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

[Synonym ]:
8-Hydrazinoadenosin
8-hydrazino-adenosine
8-hydrazinyl-9-pentofuranosyl-9h-purin-6-amine

Biological Activity

[Description]:

8-Hydrazinoadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.29g/cm3

[ Boiling Point ]:
748.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₅N₇O₄

[ Molecular Weight ]:
297.27

[ Flash Point ]:
406.7ºC

[ Exact Mass ]:
297.11900

[ PSA ]:
177.59000

[ Index of Refraction ]:
2.002