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Metofenazate

Names

[ CAS No. ]:
388-51-2

[ Name ]:
Metofenazate

[Synonym ]:
2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate
Metofenazate [INN]
1-<2-(3,4,5-Trimethoxy-benzoyloxy)-ethyl>-4-(3-<2-chlor-phenothiazinyl-(10)>-propyl)-piperazin
Metofenazatum
Metofenazato [INN-Spanish]
Frenolon
Metofenazatum [INN-Latin]
1-(3-<2-Chlor-phenothiazinyl-(10)>-propyl)-4-<2-(3,4,5-trimethoxy-benzoyloxy)-ethyl>-piperazin
Metofenazato
Methophenazine
perphenazine
3,4,5-trimethoxy-benzoic acid 2-{4-[3-(2-chloro-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl ester

Biological Activity

[Description]:

Metofenazate is a selective calmodulin inhibitor.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> CaMK
Research Areas >> Neurological Disease

[Target]

Calmodulin[1]


[References]

[1]. Tkachuk VA, et al. Metofenazate as a more selective calmodulin inhibitor than trifluoperazine. Arzneimittelforschung. 1987 Sep;37(9):1013-7.


[Related Small Molecules]

KN-93 | STO609 | KN-62 | KN-92-hydrochloride | CaMKII-IN-1 | MLCK inhibitor peptide 18 | Autocamtide-2 | A 484954 | Rimacalib | Calmodulin-Dependent Protein Kinase II (290-309) | NH 125 | Syntide 2 trifluoroacetate salt

Chemical & Physical Properties

[ Density]:
1.248 g/cm3

[ Boiling Point ]:
694.7ºC at 760 mmHg

[ Molecular Formula ]:
C31H36ClN3O5S

[ Molecular Weight ]:
598.15300

[ Flash Point ]:
374ºC

[ Exact Mass ]:
597.20600

[ PSA ]:
89.01000

[ LogP ]:
5.77400

[ Index of Refraction ]:
1.6

[ Storage condition ]:
2-8℃

Related Compounds