NSC693868

Names

[ Name ]:
NSC693868

[Synonym ]:
MFCD04038461

Biological Activity

[Description]:

NSC693868 is a selective inhibitor of CDK1 and CDK5 with IC50s of 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with an IC50 of 1 µM) and does not block CDC25 activity. NSC693868 is used to help define the roles of CDK1 and CDK5 in various signaling pathways[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

Cdk1/cyclin B:600 nM (IC50)

Cdk5/p25:400 nM (IC50)

GSK-3β:1 μM (IC50)

[References]

[1]. Ortega MA, et al. Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg Med Chem. 2002 Jul;10(7):2177-84.

Chemical & Physical Properties

[ Density]:
1.57g/cm3

[ Boiling Point ]:
522.8ºC at 760mmHg

[ Molecular Formula ]:
C₉H₇N₅

[ Molecular Weight ]:
185.18500

[ Flash Point ]:
303ºC

[ Exact Mass ]:
185.07000

[ PSA ]:
80.48000

[ LogP ]:
1.66950

[ Index of Refraction ]:
1.9

Safety Information

[ Hazard Codes ]:
T+

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%