N6-Cyclopentyladenosine

Names

[ Name ]:
N6-Cyclopentyladenosine

[Synonym ]:
N6-Cyclopentyladenosine

Biological Activity

[Description]:

N6-Cyclopentyladenosine (CPA) is a selective Adenosine A1 receptor agonist, with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

Ki: 2.3 nM (A1), 790 nM (A2A), 43 nM(A3)[1].

[References]

[1]. Klotz KN, et al. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):382-91.

[2]. Soliño M, et al. Adenosine A1 receptor: A neuroprotective target in light induced retinal degeneration. PLoS One. 2018 Jun 18;13(6):e0198838.

Chemical & Physical Properties

[ Density]:
1.78g/cm3

[ Boiling Point ]:
673.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₁N₅O₄

[ Molecular Weight ]:
335.36

[ Flash Point ]:
361.1ºC

[ Exact Mass ]:
335.15900

[ PSA ]:
125.55000

[ Index of Refraction ]:
1.816

[ Storage condition ]:
2-8℃

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

The effect of pH and ion channel modulators on human placental arteries.

PLoS ONE 9(12) , e114405, (2014)

Chorionic plate arteries (CPA) are located at the maternofetal interface where they are able to respond to local metabolic changes. Unlike many other types of vasculature, the placenta lacks nervous c...

Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium.

Arthritis. Res. Ther. 16(3) , R121, (2014)

Acid-sensing ion channel 3 (ASIC3) is expressed in synoviocytes, activated by decreases in pH, and reduces inflammation in animal models of inflammatory arthritis. The purpose of the current study was...

Chemoenzymatic Syntheses of Sialylated Oligosaccharides Containing C5-Modified Neuraminic Acids for Dual Inhibition of Hemagglutinins and Neuraminidases.

Chemistry 21 , 10903-12, (2015)

A fast chemoenzymatic synthesis of sialylated oligosaccharides containing C5-modified neuraminic acids is reported. Analogues of GM3 and GM2 ganglioside saccharidic portions where the acetyl group of ...