Filastatin

Names

[ CAS No. ]:
431996-53-1

[ Name ]:
Filastatin

[Synonym ]:
Filastatin

Biological Activity

[Description]:

Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Ahmed Fazly, et al. Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13594-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₈ClN₃O₃

[ Molecular Weight ]:
359.80700

[ Exact Mass ]:
359.10400

[ PSA ]:
69.37000

[ LogP ]:
4.04510

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H410

[ Precautionary Statements ]:
P261-P273-P305 + P351 + P338-P501

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 3077 9 / PGIII