2'-O-MOE-N2-ibu-rG

Names

[ Name ]:
2'-O-MOE-N2-ibu-rG

[Synonym ]:
Guanosine,2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)
2'-O-MOE-N2-ibu-rG

Biological Activity

[Description]:

N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₅N₅O₇

[ Molecular Weight ]:
411.41

[ Exact Mass ]:
411.17500

[ PSA ]:
164.57000

[ LogP ]:
0.05810

2'-O-MOE-N2-ibu-rG

Names

Biological Activity

Chemical & Physical Properties

Related Compounds