Besifovir

Names

[ Name ]:
Besifovir

[Synonym ]:
UNII-4PLG22CQUU
[({1-[(2-Amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methyl]phosphonic acid
Besifovir
Phosphonic acid, [[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]-

Biological Activity

[Description]:

Besifovir (LB80331), a parent drug converted by LB80380, further metabolizes to its active form, LB80317. LB80380 is potent antiviral agent against hepatitis B virus (HBV) [1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

[References]

[1]. Jung JA, et al. Pharmacokinetic comparison of the maleate and free base formulations of LB80380, a novel nucleotide analog, in healthy male volunteers. Int J Clin Pharmacol Ther. 2012 Sep;50(9):657-64.

[2]. Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83.

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
668.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₄N₅O₄P

[ Molecular Weight ]:
299.223

[ Flash Point ]:
358.0±34.3 °C

[ Exact Mass ]:
299.078339

[ PSA ]:
146.19000

[ LogP ]:
-2.56

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.826

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%