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SB-681323

Names

[ CAS No. ]:
444606-18-2

[ Name ]:
SB-681323

[Synonym ]:
Dilmapimod
UNII-Q3238VQW0N
SB-681323

Biological Activity

[Description]:

Dilmapimod (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Research Areas >> Inflammation/Immunology

[In Vitro]

Dilmapimod (SB-681323) potently inhibits p38 MAPK signaling, measured by inhibition of sorbitol-induced pHSP27 expression[1].

[References]

[1]. Singh D, et al. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol. 2010 Jan;50(1):94-100.


[Related Small Molecules]

SB203580 | SB202190 (FHPI) | Doramapimod (BIRB 796) | LY2228820 | SB 239063 | Losmapimod | PD 169316 | Talmapimod | Tat-NR2B9c | Dehydrocorydaline chloride | TAK-715 | VX 702 | VX-745 | SKF 86002 | Acumapimod

Chemical & Physical Properties

[ Molecular Formula ]:
C23H19F3N4O3

[ Molecular Weight ]:
456.41700

[ Exact Mass ]:
456.14100

[ PSA ]:
103.50000

[ LogP ]:
2.36040

Related Compounds