FR252384

Names

[ CAS No. ]:
447405-11-0

[ Name ]:
FR252384

Biological Activity

[Description]:

FR252384 is a neuropeptide Y-Y5 receptor antagonist, with an IC50 of 2.3 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

Research Areas >> Others

[Target]

IC50: 2.3 nM (neuropeptide Y-Y5 receptor)[1]

[In Vivo]

FR252384 is orally absorbable and permeable to brain[1].

[References]

[1]. Satoh Y, et al. Novel potent antagonists of human neuropeptide Y-Y5 receptor. Part 4: tetrahydrodiazabenzazulene derivatives. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1009-11.

[Related Small Molecules]

Velneperit | MK 0557 | HT-2157 | BIIE 0246 | Galanin (1-16) (mouse, porcine, rat) | JNJ-31020028 | CGP 71683 HCl | Galanin (human) acetate salt | Galanin (1-13)-Substance P (5-11) amide | Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide | Neuropeptide Y (13-36) (human, rat) trifluoroacetate salt | Neuropeptide Y(29-64) | Pancreatic Polypeptide, bovine | Pancreatic Polypeptide (human) trifluoroacetate salt

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₇N₃

[ Molecular Weight ]:
275.35