JAK3-IN-14

Names

[ Name ]:
JAK3-IN-14

Biological Activity

[Description]:

JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

[Target]

JAK3:38 nM (IC50)

JAK2:600 nM (IC50)

[References]

[1]. Chen JJ, et al. Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5633-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₃N₃O

[ Molecular Weight ]:
287.32

[ Exact Mass ]:
287.10600

[ PSA ]:
57.78000

[ LogP ]:
3.70740