Sordarin sodium

Names

[ Name ]:
Sordarin sodium

Biological Activity

[Description]:

Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicans, C. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae)[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Inflammation/Immunology

[Target]

IC50: eEF2; fungal[1]

[References]

[1]. Wael Abdel-Fattah, et al. Insights into diphthamide, key diphtheria toxin effector. Toxins (Basel). 2013 May 3;5(5):958-68.

[2]. Biprashekhar Chakraborty, et al. Structure-based designing of sordarin derivative as potential fungicide with pan-fungal activity. J Mol Graph Model. 2016 May;66:133-42.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₉NaO₈

[ Molecular Weight ]:
514.58

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Articles

Insights into diphthamide, key diphtheria toxin effector.

Toxins (Basel.) 5(5) , 958-68, (2013)

Diphtheria toxin (DT) inhibits eukaryotic translation elongation factor 2 (eEF2) by ADP-ribosylation in a fashion that requires diphthamide, a modified histidine residue on eEF2. In budding yeast, dip...