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CYCLOARTENOL

Names

[ CAS No. ]:
469-38-5

[ Name ]:
CYCLOARTENOL

[Synonym ]:
CYCLOARTENOL
9,19-Cyclolanost-24-en-3-ol
9,19-CYCLO-9BETA-LANOST-24-EN-3BETA-OL

Biological Activity

[Description]:

Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

[In Vitro]

Cycloartenol inhibits the proliferation and the colony formation potential of the glioma U87 cells in a concentration-dependent manner. The antiproliferative effects are found to be due to induction of Sub-G1 cell cycle arrest and triggering of apoptosis. Cycloartenol also causes significant alteration in the expression of Bax and Bcl-2[2].

[References]

[1]. Niu H, et al. Cycloartenol exerts anti-proliferative effects on Glioma U87 cells via induction of cell cycle arrest and p38 MAPK-mediated apoptosis. J BUON. 2018 Nov-Dec;23(6):1840-1845.

[2]. Zhang ZL, et al. [Research advance of functional plant pharmaceutical cycloartenol about pharmacological and physiological activity]. Zhongguo Zhong Yao Za Zhi. 2017 Feb;42(3):433-437.

Chemical & Physical Properties

[ Density]:
1.01 g/cm3

[ Boiling Point ]:
505.5ºC at 760 mmHg

[ Melting Point ]:
115-117ºC

[ Molecular Formula ]:
C30H50O

[ Molecular Weight ]:
426.71700

[ Flash Point ]:
221.9ºC

[ Exact Mass ]:
426.38600

[ PSA ]:
20.23000

[ LogP ]:
8.16890

[ Vapour Pressure ]:
2.47E-12mmHg at 25°C

[ Index of Refraction ]:
1.538

MSDS

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Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Safety Phrases ]:
22-24/25

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds