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GW438014A

Names

[ CAS No. ]:
469861-49-2

[ Name ]:
GW438014A

[Synonym ]:
Benzamide, N-[1-(2-phenylethyl)-1H-benzimidazol-2-yl]-, methanesulfonate (1:1)
N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide methanesulfonate (1:1)

Biological Activity

[Description]:

GW438014A is a potent and selective NPY-Y5 receptor antagonist. GW438014A inhibits food intake and reduces body weight gain in obese rodents[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[In Vivo]

GW438014A (10 mg/kg; i.p.; daily, for 7 d) 抑制大鼠和食物剥夺的遗传性肥胖 ob/ob 小鼠的自发和过夜禁食诱导和 NPY 诱导的摄食[1]。 Animal Model: obese ob/ob mice[1] Dosage: 10 mg/kg Administration: intraperitoneal injection; daily, for 7 d Result: Decreased the rate of weight gain in both lean and obese rats.

[References]

[1]. Daniels AJ, et, al. Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul Pept. 2002 Jun 15;106(1-3):47-54.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H23N3O4S

[ Molecular Weight ]:
437.51

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Hazard Codes ]:
T+

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds