Corydamine

Names

[ Name ]:
Corydamine

[Synonym ]:
[2-(6-[1,3]Dioxolo[4,5-h]isoquinolin-7-yl-benzo[1,3]dioxol-5-yl)-ethyl]-methyl-amine
[2-(6-[1,3]dioxolo[4,5-h]isoquinolin-7-yl-benzo[1,3]dioxol-5-yl)-ethyl]-methyl-amine
Corydamin
2-[6-([1,3]dioxolo[4,5-h]isoquinolin-7-yl)-1,3-benzodioxol-5-yl]-N-methylethanamine

Biological Activity

[Description]:

Corydamine, 3-arylisoquinoline alkaloid, is a potent DNA topoisomerase I/II inhibitor. Corydamine has anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[Target]

Topoisomerase I

Topoisomerase II

[References]

[1]. Xuemei Deng, et al. Design, synthesis and anti-hepatocellular carcinoma activity of 3-arylisoquinoline alkaloids. Eur J Med Chem. 2022 Jan 15;228:113985.

Chemical & Physical Properties

[ Density]:
1.334±0.06 g/cm3

[ Boiling Point ]:
545.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₈N₂O₄

[ Molecular Weight ]:
350.36800

[ Exact Mass ]:
350.12700

[ PSA ]:
61.84000

[ LogP ]:
3.51200