AR03

Names

[ Name ]:
AR03

[Synonym ]:
2,4,9-Trimethyl-benzo[b][1,8]naphthyridin-5-ylamine
HMS2537D20

Biological Activity

[Description]:

AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[Target]

IC50: 2.1 µM (Ape1)[1]

[References]

[1]. Aditi Bapat, et al. Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells. J Pharmacol Exp Ther. 2010 Sep 1;334(3):988-98.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₅N₃

[ Molecular Weight ]:
237.30

[ Exact Mass ]:
237.12700

[ PSA ]:
51.80000

[ LogP ]:
3.87160

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%