Agoniadin

Names

[ CAS No. ]:
511-89-7

[ Name ]:
Agoniadin

[Synonym ]:
1-(b-D-Glucopyranosyloxy)-4a,7a-dihydro-4'-(1-hydroxyethyl)-5'-oxospiro[cyclopenta[c]pyran-7(1H),2'(5'H)-furan]-4-carboxylic Acid Methyl Ester
Spiro[cyclopenta[c]pyran-7(1H),2'(5'H)-furan]-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-4a,7a-dihydro-4'-[(1S)-1-hydroxyethyl]-5'-oxo-, methyl ester, (1S,4aS,7R,7aS)-
Agoniadin
Methyl (1S,4aS,7R,7aS)-1-(β-D-glucopyranosyloxy)-4'-[(1S)-1-hydroxyethyl]-5'-oxo-4a,7a-dihydro-1H,5'H-spiro[cyclopenta[c]pyran-7,2'-furan]-4-carboxylate
Plumieride

Biological Activity

[Description]:

Plumieride is an antifungal agent. Plumieride has strong fungitoxicity against some dermatophytes. Plumieride has little cytotoxic activity against the P388 leukaemia cell line with an IC50 of 85 μg/mL[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Tiwari TN, et al. Plumieride from Allamanda cathartica as an antidermatophytic agent. Phytother Res. 2002 Jun;16(4):393-4.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
771.4±60.0 °C at 760 mmHg

[ Melting Point ]:
156-158°; mp 224-225°

[ Molecular Formula ]:
C₂₁H₂₆O₁₂

[ Molecular Weight ]:
470.42

[ Flash Point ]:
269.2±26.4 °C

[ Exact Mass ]:
470.142426

[ PSA ]:
181.44000

[ LogP ]:
-4.23

[ Vapour Pressure ]:
0.0±6.0 mmHg at 25°C

[ Index of Refraction ]:
1.645

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Articles

Assessment of the genotoxic and mutagenic properties of Himatanthus articulatus bark extracts used as phytotherapeutic drug in the Amazon.

J. Ethnopharmacol. 147(2) , 474-80, (2013)

Himatanthus articulatus (Apocynaceae) is a plant native to the Amazon, popularly used to treat external ulcers, tumors, inflammations, cancer, syphilis and malaria.To investigate the in vivo genotoxic...

Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest.

J. Nat. Prod. 60(12) , 1294-7, (1997)

Bioassay-guided fractionation of the EtOAc extract of both Allamanda cathartica and Himatanthus fallax (Apocynaceae) using the Sc-7 yeast strain resulted in the isolation of the weakly cytotoxic isopl...

Structural modifications of plumieride isolated from Plumeria bicolor and the effect of these modifications on in vitro anticancer activity.

J. Org. Chem. 69(19) , 6165-72, (2004)

Plumieride was isolated as one of the major components from the biologically active methanolic extract of the bark of Plumeria bicolor (family Apocynaceae). For investigating the effect of substituent...