Carboxin
Names
[ CAS No. ]:
5234-68-4
[ Name ]:
Carboxin
[Synonym ]:
2-Methyl-N-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide
N3-Phenyl-2-methyl-5,6-dihydro-1,4-oxathiine-3-carboxamide
5,6-dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide
CARBOXIN
Vitavax 735D
6-methyl-N-phenyl-2,3-dihydro-1,4-oxathiine-5-carboxamide
2,3-dihydro-6-methyl-5-phenylcarbamyl-1,4-oxathiin
Vitavax 100
Carbathiine
MFCD00055403
EINECS 226-031-1
Carbathiin
5,6-Dihydro-2-methyl-1,4-oxathiine-3-carboxanilide
Vitavax 75W
1,4-Oxathiin-3-carboxamide, 5,6-dihydro-2-methyl-N-phenyl-
T6O DS BUTJ B1 CVMR
2,3-dihydro-5-carboxanilido-6-methyl-1,4-oxathiin
5,6-Dihydro-3-methyl-N-phenyl-1,4-oxathin-2-carboxamide
Vitavax
Carboxine
DMOC
DCMO
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
420.6±45.0 °C at 760 mmHg
[ Melting Point ]:
91.1-91.7°C
[ Molecular Formula ]:
C12H13NO2S
[ Molecular Weight ]:
235.302
[ Flash Point ]:
208.2±28.7 °C
[ Exact Mass ]:
235.066696
[ PSA ]:
63.63000
[ LogP ]:
3.00
[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C
[ Index of Refraction ]:
1.636
[ Water Solubility ]:
10.095 g/100 mL
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RP4550000
- CHEMICAL NAME :
- 1,4-Oxathiin-3-carboxamide, 5,6-dihydro-2-methyl-N-phenyl-
- CAS REGISTRY NUMBER :
- 5234-68-4
- BEILSTEIN REFERENCE NO. :
- 0983249
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C12-H13-N-O2-S
- MOLECULAR WEIGHT :
- 235.32
- WISWESSER LINE NOTATION :
- T6O DS BUTJ B1 CVMR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 430 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >20 gm/m3/1H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1050 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3200 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 8 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 24 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 3200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 42200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 54300 ug/m3/4H/6W-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 161 gm/kg/2Y-I
- TOXIC EFFECTS :
- Gastrointestinal - other changes Liver - fatty liver degeneration Blood - changes in erythrocyte (RBC) count
MUTATION DATA
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 382 mg/kg/48H (Continuous)
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12,235,1988 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xi,Xn
[ Risk Phrases ]:
R21/22
[ Safety Phrases ]:
36-26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
RP4550000
[ HS Code ]:
2934999038
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999038
[ Summary ]:
2934999038 2-methyl-n-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide 4,4-dioxide。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%
Articles
Microbiol. Res. 172 , 57-67, (2015)
Zymography of alcohol dehydrogenase (ADH) activity in the entomopathogenic fungus Metarhizium anisopliae grown under various conditions revealed that micro-aerobic growth was associated with increased...
Controlling food-contaminating fungi by targeting their antioxidative stress-response system with natural phenolic compounds.Appl. Microbiol. Biotechnol. 70(6) , 735-9, (2006)
The antioxidative stress-response system is essential to fungi for tolerating exposure to phenolic compounds. We show how this system can be targeted to improve fungal control by using compounds that ...
Phototransformation of carboxin in water. Toxicity of the pesticide and its sulfoxide to aquatic organisms.J. Agric. Food Chem. 52(20) , 6228-32, (2004)
Sunlight exposure of aqueous suspensions of carboxin (1) causes its phototransformation to sulfoxide 2 and minor components. Similar effects are observed in the presence of humic acid or nitrate or at...