β-Nor-lapachone

Names

[ CAS No. ]:
52436-88-1

[ Name ]:
β-Nor-lapachone

[Synonym ]:
Naphtho[1,2-b]furan-4,5-dione,2,3-dihydro-2,2-dimethyl

Biological Activity

[Description]:

β-Nor-lapachone is a Candida glabrata antibiofilm agent. β-Nor-lapachone can stimulate ROS production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. β-Nor-lapachone has antifungal activity[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS

[Target]

Candida glabrata, ROS[1]


[References]

[1]. Clemente de Moraes D, et al. Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata. Bioorg Med Chem. 2022;63:116749.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H12O3

[ Molecular Weight ]:
228.24

[ Exact Mass ]:
228.07900

[ PSA ]:
43.37000

[ LogP ]:
2.36200

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds