PSB 36

Names

[ Name ]:
PSB 36

[Synonym ]:
hms3268h03

Biological Activity

[Description]:

PSB36 is a potent and selective antagonist of adenosine A1 receptor, with Kis 0.12 nM, 187 nM, 552 nM, 2300 nM, and 6500 nM for rA1, hA2B, rA2A, hA3 and rA3 receptors respectively. PSB36 can be used for the research of hyperalgesia[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

rA1:0.12 nM (Ki)

hA2B:187 nM (Ki)

rA2A:552 nM (Ki)

hA3:2300 nM (Ki)

rA3:6500 nM (Ki)

[References]

[1]. Abo-Salem OM, et, al. Antinociceptive effects of novel A2B adenosine receptor antagonists. J Pharmacol Exp Ther. 2004 Jan;308(1):358-66.

[2]. Bilkei-Gorzo A, et, al. Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia. Naunyn Schmiedebergs Arch Pharmacol. 2008 Mar;377(1):65-76.

Chemical & Physical Properties

[ Density]:
1.304g/cm3

[ Boiling Point ]:
646.008ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₀N₄O₃

[ Molecular Weight ]:
386.48800

[ Flash Point ]:
344.493ºC

[ Exact Mass ]:
386.23200

[ PSA ]:
92.91000

[ LogP ]:
2.14650

[ Index of Refraction ]:
1.616

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

The protective effects of CD39 overexpression in multiple low-dose streptozotocin-induced diabetes in mice.

Diabetes 62(6) , 2026-35, (2013)

Islet allograft survival limits the long-term success of islet transplantation as a potential curative therapy for type 1 diabetes. A number of factors compromise islet survival, including recurrent d...

Diadenosine diphosphate (Ap₂A) delays neutrophil apoptosis via the adenosine A2A receptor and cAMP/PKA pathway.

Biochem. Cell Biol. 92(5) , 420-4, (2014)

Diadenosine polyphosphates have been shown to inhibit neutrophil apoptosis, but mechanisms of the antiapoptotic effect are not known. Diadenosine diphosphate (Ap2A) is the simplest naturally occurring...

Antinociceptive effects of novel A2B adenosine receptor antagonists.

J. Pharmacol. Exp. Ther. 308 , 358-366, (2004)

Caffeine, an adenosine A1, A2A, and A2B receptor antagonist, is frequently used as an adjuvant analgesic in combination with nonsteroidal anti-inflammatory drugs or opioids. In this study, we have exa...