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Caulophyllogenin

Names

[ CAS No. ]:
52936-64-8

[ Name ]:
Caulophyllogenin

[Synonym ]:
Caulophyllogenin
EINECS 258-265-5

Biological Activity

[Description]:

Caulophyllogenin is a triterpene saponin extracted from M. polimorpha. Caulophyllogenin is a partial PPARγ agonist, with an EC50 of 12.6 μM. Caulophyllogenin can be used for the research of type-2 diabetes, obesity, metabolic syndrome and inflammation[1][2].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[Target]

PPARγ:12.6 μM (EC50)


[References]

[1]. Montanari R, et, al. Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin. Sci Rep. 2016 Jun 10; 6:27658.

[2]. Zhang Y, et, al. Studies on cytotoxic triterpene saponins from the leaves of Aralia elata. Food Chem. 2013 May 1;138(1):208-13.

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
621.5ºC at 760mmHg

[ Melting Point ]:
>300ºC (dec.)

[ Molecular Formula ]:
C30H48O5

[ Molecular Weight ]:
488.69900

[ Flash Point ]:
343.7ºC

[ Exact Mass ]:
488.35000

[ PSA ]:
97.99000

[ LogP ]:
5.17680

[ Index of Refraction ]:
1.58

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Related Compounds